Stage III Bladder Cancer

May 11th, 2009

Stage III bladder cancer is classified as a 'deep' or 'invasive' bladder cancer. A variety of factors ultimately influence a patient's decision to receive treatment of cancer. The potential benefits of receiving cancer treatment must be carefully balanced with the potential risks of receiving cancer treatment.
The following is a general overview of the treatment of Stage III bladder cancer. The development of more effective cancer treatments requires that new and innovative therapies be evaluated with cancer patients. Clinical trials are available for most stages of cancer. 

Surgery as Primary Treatment
Radical cystectomy is considered a standard treatment for Stage III bladder cancer. To learn more about cystectomy, go to Surgery for Bladder Cancer.

Chemotherapy Prior to Cystectomy
Following a radical cystectomy, local recurrence of cancer is uncommon because the cancer was removed. The rationale behind neoadjuvant therapy for bladder cancer is two-fold. First, pre-operative treatment can shrink some bladder cancers and therefore, may allow more complete surgical removal of the cancer. 

Chemotherapy and Radiation Therapy as Primary Treatment
Bladder-preserving therapy is appealing because patients who achieve a complete response to treatment can often avoid additional treatment with a radical cystectomy unless they experience recurrence of their cancer. In addition to avoiding a cystectomy, early treatment with chemotherapy may also kill bladder cancer cells that have already spread away from the bladder.
Furthermore, only selected patients with Stage III bladder cancer will be candidates for bladder-preserving therapy. 
Chemotherapy Alone as Primary Treatment
Chemotherapy without radiation therapy may be used for selected patients with inoperable stage III cancer, or for patients who cannot tolerate more extensive treatment.[2]
Radiation Therapy Alone as Primary Treatment
To learn more go to Radiation Therapy for Bladder Cancer.
Questions to Ask Your Physician About the Treatment of Stage III Bladder Cancer
Strategies to Improve Treatment

The progress that has been made in the treatment of bladder cancer has resulted from improved treatment developed in clinical trials. Adjuvant therapy is a treatment that follows surgical cystectomy. Adjuvant chemotherapy is still being evaluated in clinical trials to prevent recurrence of bladder cancer. Multiple Drug Resistance Inhibitors: Bladder cancer can be drug resistant at the outset of treatment. Gene Therapy: Currently, there are no gene therapies approved for the treatment of bladder cancer. A few gene therapy studies are being carried out in patients with refractory bladder cancer.